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先导药物筛选
技术服务
先导药物筛选
自动化噬菌体展示
噬菌体展示技术(Phage display technology)是指将外源蛋白或多肽的DNA序列插入到噬菌体外壳结构蛋白基因的适当位置,使外源基因随外壳蛋白的表达而表达。同时,随着噬菌体的传代,外源蛋白随噬菌体的重新组装而展示到噬菌体表面,形成噬菌体文库。随后用特定蛋白对噬菌体文库进行筛选,便可快速的得到与该蛋白具有高度亲和力的抗体。筛选出的抗体可以用于下一步的生物学功能研究。Scilia基于自身智能化和自动化平台,将噬菌体展示技术和工程自动化技术结合,可精细完成批量重复操作实验,构建可追溯的实验结果、数据库和AI模型。Scilia自动化噬菌体展示平台提供更优化的抗体基因引物设计,确保高成功率和抗体多样性的获得、建库类型灵活以及库容量大等特点。
自动化高通量筛选
高通量筛选 (High throughput screening,HTS)是指以分子或和细胞水平的实验方法为基础,采用不同密度的微孔平板作为实验载体和自动化工具操作实验步骤,通过快速灵敏的检测装置在同一时间内对海量样品进行生物活性测定、采集实验数据和数字化分析处理,并通过相应的信息管理软件支持整个系统正常运转的技术体系。Scilia自动化高通量筛选平台依托多种先进的实验仪器和制造工艺,以药物与靶分子或靶细胞之间的作用机理为依据进行生物活性分析,通过整合计算机控制、自动化操作、平行多道检测和数据采集处理等各个步骤,实现了对海量样品微量、快速、灵敏和准确测定分析的目标,将助力早期药物发现及药物功能结构研究。
筛选类型
Scilia具有大量的化合物库,这些活性小分子可以广泛地应用于高通量筛选(HTS)和高内涵筛选(HCS)。化合物筛选库已经成为新药研发以及新适应症探索的重要工具。

临床和上市相关

FDA上市及药典收录化合物库
FDA Approved &Pharmacopeial Drug Library
2965 compounds
NMPA上市药物库
NMPA-Approved Drug Library
1171 compounds
临床化合物库
Clinical Compound Library
1569 compounds
老药新用化合物库
Drug Repurposing Compound Library
3613 compounds

疾病相关

抗COVID-19化合物库
Anti-COVID-19 Compound Library
1502 compounds
抗肿瘤化合物库
Anti-Cancer Compound Library
4842 compounds
肿瘤免疫小分子化合物库
Small Molecule Immuno-Oncology Compound Library
303 compounds
抗肿瘤代谢化合物库
Anti-Cancer Metabolism Compound Library
797 compounds
抗丙型肝炎病毒化合物库
Anti-Hepatitis C Virus Compound Library
192 compounds
靶向治疗药物库
Targeted Therapy Drug Library
103 compounds
抗血液肿瘤化合物库
Anti-Blood Cancer Compound Library
1757 compounds
抗肺癌化合物库
Anti-Lung Cancer Compound Library
704 compounds
抗乳腺癌化合物库
Anti-Breast Cancer Compound Library
1271 compounds
抗感染化合物库
Anti-Infection Compound Library
1756 compounds
抗寄生虫化合物库
Antiparasitic Compound library
263 compounds
抗病毒化合物库
Antiviral Compound Library
606 compounds
神经退行性疾病化合物库
Neurodegenerative Disease-related Compound Library
1368 compounds
抗阿尔茨海默病化合物库
Anti-Alzheimer's Disease Compound Library
889 compounds
抗帕金森病化合物库
Anti-Parkinson's Disease Compound Library
811 compounds
抗胰腺癌化合物库
Anti-Pancreatic Cancer Compound Library
1585 compounds
抗衰老化合物库
Anti-Aging Compound Library
2650 compounds
神经保护化合物库
Neuroprotective Compound Library
648 compounds
糖尿病化合物库
Diabetes Related Compound Library
506 compounds
抗肥胖化合物库
Anti-Obesity Compound Library
363 compounds
抗心血管疾病化合物库
Anti-Cardiovascular Disease Compound Library
886 compounds
内分泌化合物库
Endocrinology Compound Library
720 compounds
抗真菌化合物库
Antifungal Compound Library
209 compounds
抗细菌化合物库
Antibacterial Compound Library
757 compounds
抗生素化合物库
Antibiotics Library
472 compounds

信号通路和蛋白家族相关

外泌体化合物库
Exosomes Compound Library
38 compounds
内质网应激化合物库
Endoplasmic Reticulum Stress Compound Library
139 compounds
线粒体靶向化合物库
Mitochondria-Targeted Compound Library
361 compounds
细胞焦亡化合物库
Pyroptosis Compound Library
749 compounds
血管生成化合物库
Angiogenesis Related Compound Library
1269 compounds
细胞骨架化合物库
Cytoskeleton Compound Library
822 compounds
神经递质受体化合物库
Neurotransmitter Receptor Compound Library
1139 compounds
谷氨酰胺代谢化合物库
Glutamine Metabolism Compound Library
569 compounds
脂代谢化合物库
Lipid Metabolism Compound Library
284 compounds
糖代谢化合物库
Glucose Metabolism Compound Library
559 compounds
抗氧化化合物库
Antioxidants Compound Library
690 compounds
诱导分化化合物库
Differentiation Inducing Compound Library
955 compounds
细胞重编程化合物库
Reprogramming Compound Library
1313 compounds
泛素化化合物库
Ubiquitination Compound Library
170 compounds
铁死亡化合物库
Ferroptosis Compound Library
573 compounds
细胞凋亡化合物库
Apoptosis Compound Library
1422 compounds
自噬化合物库
Autophagy Compound Library
1110 compounds
糖酵解化合物库
Glycolysis Compound Library
449 compounds
细胞周期/DNA损伤化合物库
Cell Cycle/DNA Damage Compound Library
1168 compounds
表观遗传化合物库
Epigenetics Compound Library
769 compounds
GPCR/G蛋白化合物库
GPCR/G Protein Compound Library
1500 compounds
组蛋白修饰化合物库
Histone Modification Research Compound Library
392 compounds
免疫/炎症化合物库
Immunology/Inflammation Compound Library
2954 compounds
JAK/STAT化合物库
JAK/STAT Compound Library
265 compounds
磷酸酶抑制剂库
Phosphatase Inhibitor Library
77 compounds
激酶抑制剂库
Kinase Inhibitor Library
2030 compounds
MAPK化合物库
MAPK Compound Library
269 compounds
膜转运蛋白/离子通道化合物库
Membrane Transporter/Ion Channel Compound Library
849 compounds
代谢/蛋白酶化合物库
Metabolism/Protease Compound Library
2572 compounds
神经信号化合物库
Neuronal Signaling Compound Library
1583 compounds
转录因子化合物库
Transcription Factor Targeted Library
785 compounds
NF-κB信号化合物库
NF-κB Signaling Compound Library
473 compounds
PI3K/Akt/mTOR化合物库
PI3K/Akt/mTOR Compound Library
382 compounds
蛋白酪氨酸激酶化合物库
Protein Tyrosine Kinase Compound Library
620 compounds
干细胞化合物库
Stem Cell Signaling Compound Library
1073 compounds
TGF-beta/Smad化合物库
TGF-beta/Smad Compound Library
130 compounds
Wnt/Hedgehog/Notch化合物库
Wnt/Hedgehog/Notch Compound Library
209 compounds
氧感应化合物库
Oxygen Sensing Compound Library
1534 compounds
联系信息
电话:400 0601 021
邮箱: officialmail@scilia.com
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